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"Obsession" is a 1983 song by Holly Knight and Michael Des Barres, covered in 1984 by American synth-pop band Animotion. The song hit number six in the United States, and number five in the United Kingdom in June 1985, helped by a distinctive video that MTV played frequently.
The existence of cannabinoid receptors in the brain was discovered from in vitro studies in the 1980s, with the receptor designated as the cannabinoid receptor type 1 or CB1. [14] [15] The DNA sequence that encodes a G-protein-coupled cannabinoid receptor in the human brain was identified and cloned in 1990.
Michael Jackson had the highest number of top hits at the Billboard Hot 100 chart during the 1980s (9 songs). In addition, Jackson remained the longest at the top of the Billboard Hot 100 chart during the 1980s (27 weeks). Madonna ranked as the most successful female artist of the 1980s, with 7 songs and 15 weeks atop the chart.
CBN was the first cannabinoid to be isolated from cannabis extract in the late 1800s. Specifically, it was discovered by Barlow Wood, Newton Spivey, and Easterfield in 1896. [ 21 ] In the early 1930s, CBN's structure was identified by Cahn , [ 22 ] [ 23 ] marking the first development of a cannabis extract .
Before the 1980s, cannabinoids were speculated to produce their physiological and behavioral effects via nonspecific interaction with cell membranes, instead of interacting with specific membrane-bound receptors. The discovery of the first cannabinoid receptors in the 1980s helped to resolve this debate. [10] These receptors are common in animals.
In vitro, CBG has identified pharmacodynamic actions and its mechanism of action appears to be from interactions with multiple targets. [1] [2] [3]CBG is a weak ligand of the cannabinoid CB 1 and CB 2 receptors with affinities (K i) of 380–2,600 nM and 153–3,460 nM, respectively.
The first approach to develop cannabinoid antagonists in the late 1980s was to modify the structure of THC, but the results were disappointing. In the early 1990s new family of cannabinoid agonists was discovered from the NSAID (non-steroidal anti-inflammatory) drug pravadoline which led to the discovery of aminoalkyl indole antagonists with ...
Classical cannabinoids are analogs of THC that are based on a dibenzopyran ring. They were developed starting in the 1960s, following the isolation of THC, [50] and were originally the only cannabinoids synthesized. [84] Classical cannabinoids include nabilone and dronabinol, and one of the best known synthetic classical cannabinoids is HU-210 ...