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Equine polysaccharide storage myopathy (EPSM, PSSM, EPSSM) is a hereditary glycogen storage disease of horses that causes exertional rhabdomyolysis.It is currently known to affect the following breeds American Quarter Horses, American Paint Horses, Warmbloods, Cobs, Dales Ponies, Thoroughbreds, Arabians, New Forest ponies, and a large number of Heavy horse breeds.
However, any horse that can store excess amounts of glycogen, usually genetic, can develop this form of ER. [1] Recurrent Exertional Rhabdomyolysis (RER) is commonly found in breeds that are high strung such as Arabians and thoroughbreds. However, any horse can develop this type of ER if it displays abnormal muscle contractions. [1]
The digestive system of the horse evolved for its grazing lifestyle, where it would almost constantly eat small amounts of roughage throughout the day. Unlike carnivores, who produce stomach acid during meals, horses constantly secrete acid [1] to help digest this source of grass, leading up to 9 gallons produced per day. [2]
In 1981, Brolin took acid for the first time with his friends, which resulted in a 12-hour trip. "It was as hopeful a day as I could’ve had," the actor wrote.
Horses can develop a number of muscle disorders, many of which may progress to rhabdomyolysis. Of these, some cause isolated attacks of rhabdomyolysis (e.g., dietary deficiency in vitamin E and selenium , poisoning associated with pasture or agricultural poisons such as organophosphates ), while others predispose to exertional rhabdomyolysis (e ...
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A "bad trip" is a highly unpleasant psychedelic experience. [8] [25] A bad trip on psilocybin, for instance, often features intense anxiety, confusion, agitation, or even psychotic episodes. [26] Bad trips can be connected to the anxious ego-dissolution (AED) dimension of the APZ questionnaire used in research on psychedelic experiences. [8]
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