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The pattern of metastasis is different for gastric signet cell carcinoma than for intestinal-type gastric carcinoma. The SRCC tumor is often seen in the peritoneum and has also been known to spread to lymphatic permeation of the lungs and to the ovaries , creating Krukenberg tumors . [ 14 ]
Signet ring cell, as seen in a case of colon adenocarcinoma with mucinous features, showing a tumor cell with a vacuole of mucin. H&E stain. Signet ring for comparison. In histology, a signet ring cell is a cell with a large vacuole. The malignant type is seen predominantly in carcinomas.
A mucinous neoplasm (also called colloid neoplasm) is an abnormal and excessive growth of tissue with associated mucin (a fluid that sometimes resembles thyroid colloid). It arises from epithelial cells that line certain internal organs and skin, and produce mucin (the main component of mucus ).
Micrograph showing typical features of adenocarcinoma on cytopathology . Vacuoles are more prominent in mucinous tumors but can be seen in serous tumors as well. Adenocarcinoma [ 1 ] ( / ˌ æ d ɪ n oʊ k ɑːr s ɪ ˈ n oʊ m ə / ; plural adenocarcinomas or adenocarcinomata / ˌ æ d ɪ n oʊ k ɑːr s ɪ ˈ n oʊ m ə t ə / ; AC ) is a ...
(B) Mucinous carcinoma: Presence of extracellular mucin (>50%) associated with ribbons or tubular structures of neoplastic epithelium. (C) Signet ring carcinoma : More than 50% of signet cells with infiltrative growth pattern (thin red arrow) or floating in large pools of mucin (thick red arrow).
Mucinous adenocarcinoma 0.2% [12] ≥25% of tumor shows extracellular mucin [1] Intraluminal mucinous material does not qualify [1] No extraprostatic origin found [1] Tumorous glands: 34βE12- and p63-[1] PSA+ and CK8/18+ [1] 4+4=8 for irregular cribriform glands floating in mucin. [1] Signet-ring adenocarcinoma 0.02% [16]
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