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Ciclosporin, also spelled cyclosporine and cyclosporin, is a calcineurin inhibitor, used as an immunosuppressant medication. It is taken orally or intravenously for rheumatoid arthritis , psoriasis , Crohn's disease , nephrotic syndrome , eczema , and in organ transplants to prevent rejection .
Cyclosporin A (ciclosporin) Cyclosporin B; Cyclosporin C; Cyclosporin D; Cyclosporin E; Cyclosporin F; Cyclosporin G; References This page was last ...
Ciclosporin is a cyclic polypeptide that has been used widely as an orally-available immunosuppressant. [1] It was originally used to prevent transplant rejection of solid organs but has also found use as an orally administered agent to treat psoriasis, [2] rheumatoid arthritis, [3] dry eye [4] and other auto-immune related conditions.
Ciclosporin is thought to bind to the cytosolic protein cyclophilin (an immunophilin) of immunocompetent lymphocytes, especially T-lymphocytes. This complex of ciclosporin and cyclophilin inhibits the phosphatase calcineurin , which under normal circumstances induces the transcription of interleukin-2 .
This page was last edited on 13 July 2011, at 16:40 (UTC).; Text is available under the Creative Commons Attribution-ShareAlike 4.0 License; additional terms may ...
Trichodysplasia spinulosa (also known by many other names, including viral-associated trichodysplasia spinulosa, viral-associated trichodysplasia, pilomatrix dysplasia and ciclosporin-induced folliculodystrophy, although the last is a misnomer) is a rare cutaneous condition that has been described almost exclusively in immunocompromised patients, usually organ transplant recipients, on ...
In 1972, Borel was involved in the discovery of the immunosuppressive effects of cyclosporin (Sandoz called Sandimmun), which was isolated by Sandoz in 1971 from a fungus that a Sandoz employee brought back from vacation in Norway.
Tolypocladium inflatum has long been of interest in biotechnology due to its production of a relatively non-cytotoxic, natural 11 amino acid [18] cyclic peptide [19] named Ciclosporin A. [13] Ciclosporin is an immunosuppressant drug used in the management of autoimmune diseases and the prevention of rejection in organ transplantation. [5]