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A bottle of Excedrin with some of the caplets. Excedrin is an over-the-counter headache pain reliever, typically in the form of tablets or caplets. It contains paracetamol, aspirin and caffeine. It was manufactured by Bristol-Myers Squibb until it was purchased by Novartis in July 2005 along with other products from BMS's over-the-counter business.
The combination was first introduced as the name Trigesic, as the formula of 125 mg paracetamol, 230 mg aspirin, and 30 mg caffeine, in July 1950 by Squibb, which is now Bristol Myers Squibb, but was recalled in the following year due to several reports that the drug might cause blood dyscrasia. [5]
The move to stop production on both drugs stems from inconsistencies with the ingredients, which are acetaminophen, aspirin, and caffeine.
In the short term, paracetamol is safe and effective when used as directed. [33] Short term adverse effects are uncommon and similar to ibuprofen, [34] but paracetamol is typically safer than nonsteroidal anti-inflammatory drugs (NSAIDs) for long-term use. [35] Paracetamol is also often used in patients who cannot tolerate NSAIDs like ibuprofen.
Calpol also comes in a form containing ibuprofen, marketed under the name Calprofen. Calpol Night, a product containing paracetamol and an antihistamine, was listed for use from 2+ months. However, this was changed and it is now only considered suitable for children over the age of 6 years. [4]
An analgesic drug, also called simply an analgesic, antalgic, pain reliever, or painkiller, is any member of the group of drugs used for pain management.Analgesics are conceptually distinct from anesthetics, which temporarily reduce, and in some instances eliminate, sensation, although analgesia and anesthesia are neurophysiologically overlapping and thus various drugs have both analgesic and ...
NSAID identification on label of generic ibuprofen, an over-the-counter non-steroidal anti-inflammatory drug. Non-steroidal anti-inflammatory drugs [1] [3] (NSAID) [1] are members of a therapeutic drug class which reduces pain, [4] decreases inflammation, decreases fever, [1] and prevents blood clots.
One meta-analysis indicated that ibuprofen is more effective than acetaminophen in children at similar doses when both are given alone. [16] Due to concerns about Reye syndrome, it is recommended that aspirin and combination products that contain aspirin not be given to children or teenagers during episodes of fever-causing illnesses. [17] [18]