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A 2014 meta-analysis found that coffee consumption (4 cups/day) was inversely associated with all-cause mortality (a 16% lower risk), as well as cardiovascular disease mortality specifically (a 21% lower risk from drinking 3 cups/day), but not with cancer mortality [10] with exception being oral cancer mortality. [11]
The U.S. Food and Drug Administration (FDA) says that most people can tolerate up to 400 milligrams of coffee a day—that lines up to between two and three 12 oz cups of the good stuff each day ...
Researchers found that drinking around three cups of coffee a day was associated with an extra 1.8 years of life, with regular cups also being associated with increased health span (time spent ...
A standard cup of coffee can contain anywhere from 95 to 200 mg of caffeine. The FDA cites 400 mg of caffeine per day "as an amount not generally associated with dangerous, negative effects." But ...
Caffeine is considered one of the most widely consumed drugs around the world. Around 80% of the world population consumes caffeine in one form or another. [2] It is found in coffee, tea, caffeinated alcoholic drinks, cocoa, chocolate, soft drinks, especially cola, and is an important component of energy drinks and other dietary supplements. [1]
Moderate coffee drinkers who drank two to three cups per day were almost 50% less likely to develop cardiometabolic disease than people who consumed a cup a day or less, according to the 2024 study.
Caffeine can accumulate in individuals with severe liver disease, increasing its half-life. [195] A 2011 review found that increased caffeine intake was associated with a variation in two genes that increase the rate of caffeine catabolism. Subjects who had this mutation on both chromosomes consumed 40 mg more caffeine per day than others. [196]
Around 36% of people in the study were morning coffee drinkers, 16% of people drank coffee throughout the day (morning, afternoon and evening) and 48% were not coffee drinkers, the researchers said.