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Fecal occult blood testing (FOBT), as its name implies, aims to detect subtle blood loss in the gastrointestinal tract, anywhere from the mouth to the colon.Positive tests ("positive stool") may result from either upper gastrointestinal bleeding or lower gastrointestinal bleeding and warrant further investigation for peptic ulcers or a malignancy (such as colorectal cancer or gastric cancer).
The stool guaiac test involves fasting from iron supplements, red meat (the blood it contains can turn the test positive), certain vegetables (which contain a chemical with peroxidase properties that can turn the test positive), and vitamin C and citrus fruits (which can turn the test falsely negative) for a period of time before the test.
Holman used simulated gastric specimens and found the Hemoccult test to have significant problems with non-specificity and false-positive results, whereas the Gastroccult test was very accurate. [12] Holman found that by 120 seconds after the developer was applied, the Hemoccult test was positive on all control samples.
Melena is a form of blood in stool which refers to the dark black, tarry feces that are commonly associated with upper gastrointestinal bleeding. [1] The black color and characteristic strong odor are caused by hemoglobin in the blood being altered by digestive enzymes and intestinal bacteria.
Anemia of chronic disease (ACD) is the second most common cause of anemia after IDA. [4] It is often fairly mild and sometimes asymptomatic, with potential symptoms including fatigue, headache, paleness, and shortness of breath. [7] It usually occurs in individuals that have chronic inflammation due to a medical condition. [3]
Cary–Blair transport medium is a solution used to preserve fecal clinical specimens and rectal swabs after collection. The medium was devised by Sylvia G. Cary and Eugene B. Blair in 1964, [1] who noted it allowed for longer-term recovery of Salmonella, Shigella, Vibrio, and Pasteurella than other transport media.
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