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  2. Addiction-related structural neuroplasticity - Wikipedia

    en.wikipedia.org/wiki/Addiction-related...

    The goal of addiction research is to find ways to prevent and reverse the effects of addiction on the brain. Theoretically, if the structural changes in the brain associated with addiction can be blocked, then the negative behaviors associated with the disease should never develop.

  3. Epigenetics of cocaine addiction - Wikipedia

    en.wikipedia.org/wiki/Epigenetics_of_cocaine...

    These transcription factors have been shown to play a role in the short-term and long-term adaptive changes in the brain. CREB has been implicated in learning, memory, and depression and enriched in cocaine users within the nucleus accumbens. CREB seems to upregulate many genes in its pathway within the reward regions of the brain.

  4. Cocaine dependence - Wikipedia

    en.wikipedia.org/wiki/Cocaine_dependence

    Cocaine is a powerful stimulant known to make users feel energetic, cheerful, talkative, etc. In time, negative side effects include increased body temperature, irregular or rapid heart rate, high blood pressure, increased risk of heart attacks, strokes and even sudden death from cardiac arrest.

  5. Addiction - Wikipedia

    en.wikipedia.org/wiki/Addiction

    Drug addiction, which belongs to the class of substance-related disorders, is a chronic and relapsing brain disorder that features drug seeking and drug abuse, despite their harmful effects. [31] This form of addiction changes brain circuitry such that the brain's reward system is compromised, [32] causing functional consequences for stress ...

  6. Scientists Uncovered a Blow From the Past: 17th Century ... - AOL

    www.aol.com/scientists-uncovered-blow-past-17th...

    Of the approximately 200 members in the genus Erythroxylum, most species contain the central nervous system stimulant tropane alkaloid, known more commonly as cocaine.Because the plant is endemic ...

  7. Substance use disorder - Wikipedia

    en.wikipedia.org/wiki/Substance_use_disorder

    In the DSM-5, the term drug addiction is synonymous with severe substance use disorder. [ 34 ] [ 39 ] The quantity of criteria met offer a rough gauge on the severity of illness, but licensed professionals will also take into account a more holistic view when assessing severity which includes specific consequences and behavioral patterns ...

  8. Substance dependence - Wikipedia

    en.wikipedia.org/wiki/Substance_dependence

    Substance dependence, also known as drug dependence, is a biopsychological situation whereby an individual's functionality is dependent on the necessitated re-consumption of a psychoactive substance because of an adaptive state that has developed within the individual from psychoactive substance consumption that results in the experience of withdrawal and that necessitates the re-consumption ...

  9. Cocaine - Wikipedia

    en.wikipedia.org/wiki/Cocaine

    Cocaine (from French cocaïne, from Spanish coca, ultimately from Quechua kúka) [13] is a tropane alkaloid that acts as a central nervous system stimulant.As an extract, it is mainly used recreationally and often illegally for its euphoric and rewarding effects.