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Other antimalarials like amodiaquine, halofantrine, and hydroxychloroquine have also been linked to pruritus, albeit less frequently and to a lesser extent. [2] Another class of medications known to occasionally cause itching is known as serotonin reuptake inhibitors. [3] Itching is one of the most frequent adverse effects of opioid therapy. [4]
Pruritus can be seen with hepatic and renal disease such as cholestasis, alcoholic liver disease, primary biliary cholangitis, hepatitis B and C, and chronic kidney disease. [ 5 ] [ 6 ] [ 7 ] Drug and alcohol use can contribute to pruritus as well so it is worthwhile to gather a social history.
The symptoms of DRESS syndrome usually begin 2 to 6 weeks but uncommonly up to 8–16 weeks after exposure to an offending drug. Symptoms generally include fever, an often itchy rash which may be morbilliform or consist mainly of macules or plaques, facial edema (i.e. swelling, which is a hallmark of the disease), enlarged and sometimes painful lymph nodes, and other symptoms due to ...
Although the exact cause of PN is unknown, PN is associated with other dermatologic conditions such as untreated or severe atopic dermatitis and systemic causes of pruritus including liver disease and end stage kidney disease. [2] The goal of treatment in PN is to decrease itching. PN is also known as Hyde prurigo nodularis, or Picker's nodules ...
An itch can be caused by various reasons. The cause of senile pruritus is not clearly known, this type of itch in elderly patients may be a result of other reasons, like: [7] allergies; drug-induced pruritus; diseases mentioned under the Classification section of this article; underlying conditions, like kidney failure or gallbladder diseases ...
Cholestatic pruritus is the sensation of itch due to nearly any liver disease, but the most commonly associated entities are primary biliary cholangitis, primary sclerosing cholangitis, obstructive choledocholithiasis, carcinoma of the bile duct, cholestasis (also see drug-induced pruritus), and chronic hepatitis C viral infection and other forms of viral hepatitis.
Beyond identifying and discontinuing the offending drug, individuals with mild symptoms may require no further treatment. Those troubled by more significant symptoms such as itching or fever may require antihistamines, topical corticosteroids, systemic corticosteroids, and/or antipyretics. Individuals with liver, lung, kidney, and/or severe ...
No definitive medical test is known for aquagenic pruritus. Rather, diagnosis is made by excluding all other possible causes of the patient's itching, including polycythemia vera. Since pruritus is a symptom of many serious diseases, it is important to rule out other causes before making a final diagnosis. [11]