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The British Thalidomide Children's Trust was set up in 1973 as part of a £20 million legal settlement between Distillers Company and 429 children with thalidomide-related disabilities. In 1997, Diageo (formed by a merger between Grand Metropolitan and Guinness, who had taken over Distillers in 1990) made a long-term financial commitment to ...
Thalidomide is racemic; while S-thalidomide is the bioactive form of the molecule, the individual enantiomers can racemize to each other due to the acidic hydrogen at the chiral centre, which is the carbon of the glutarimide ring bonded to the phthalimide substituent. The racemization process can occur in vivo.
David Leslie Mason OBE (born 15 March 1939) is a London art dealer and Thalidomide parent activist. He is the father of a daughter, Louise, disabled by thalidomide. Mason was educated at Highgate School, where he studied under Kyffin Williams. [1]
Thalidomide had been developed by Grunenthal with whom, in July 1957, DCBL signed a sixteen-year contract to market the drug. DCBL ordered 6,000 tablets for clinical trial and 500 grammes of pure substance for animal experiments and formulation. Thalidomide was marketed in the United Kingdom under the name Distaval, beginning on 14 April 1958.
On the history of the Contergan (thalidomide) catastrophe in the light of drug legislation, Dtsch Med Wochenschr. 2001 October 19;126(42):1183-6. Shah RR., Thalidomide, drug safety and early drug regulation in the UK, Adverse Drug React Toxicol Rev. 2001 Dec;20(4):199-255.
Fraser was one of the original co-hosts of the BBC's Ouch! Podcast. [29] He presented the short-lived Channel 4 series Freak Out. [30] He presented the 2004 Channel 4 documentary Happy Birthday Thalidomide, documenting how the drug was being used in Brazil to treat leprosy, but that its use in a country with low levels of literacy and a black market in drugs was leading to new thalidomide births.
For information regarding birth defects, see thalidomide. Very common (may affect more than 1 in 10 people) Somnolence (drowsiness; ~40%) Edema (~60%)
Len and Terry Wiles c. 1970. Terrence 'Terry' Wiles (born 12 January 1962) was one of the most visible thalidomide babies born in the United Kingdom. He has since become known internationally through the Emmy Award winning [1] [2] television drama On Giant's Shoulders and the best-selling book of the same name.