Search results
Results From The WOW.Com Content Network
The isostere concept was formulated by Irving Langmuir in 1919, [3] and later modified by Grimm. Hans Erlenmeyer extended the concept to biological systems in 1932. [ 4 ] [ 5 ] [ 6 ] Classical isosteres are defined as being atoms, ions and molecules that had identical outer shells of electrons, This definition has now been broadened to include ...
Silafluofen is an isostere of pyrethroid insecticides. Silafluofen is an organosilicon analogue of pyrethroid insecticide Etofenprox , wherein a carbon center has been replaced by isosteric silicon, and in addition, one hydrogen atom is replaced by isosteric fluorine atom.
Grimm's Hydride Displacement Law is an early hypothesis, formulated in 1925, to describe bioisosterism, the ability of certain chemical groups to function as or mimic other chemical groups.
In organic chemistry, endo–exo isomerism is a special type of stereoisomerism found in organic compounds with a substituent on a bridged ring system. [1] The prefix endo is reserved for the isomer with the substituent located closest, or "syn", to the longest bridge.
Pages for logged out editors learn more. Contributions; Talk; Isosteric
Trifluoromethyl group covalently bonded to an R group. The trifluoromethyl group is a functional group that has the formula-CF 3.The naming of is group is derived from the methyl group (which has the formula -CH 3), by replacing each hydrogen atom by a fluorine atom.
Baldwin rules. Baldwin's rules in organic chemistry are a series of guidelines outlining the relative favorabilities of ring closure reactions in alicyclic compounds. They were first proposed by Jack Baldwin in 1976.
It is an isostere and isomer of purine. However, in 5-aza-7-deazapurine, N-9 of five-membered ring does not bond with hydrogen. So 5-aza-7-deazapurine derivatives must have an exocyclic substituent with a double bond to bind a sugar residue. [2] 5-Aza-7-deazapurine nucleosides may have an oxo, thioxo, or a imine group.