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A research design that involves multiple measures of the same variable taken on the same or matched subjects either under different conditions or over two or more time periods. [ 1 ] Paired t-test , Wilcoxon signed-rank test
The history of scientific method considers changes in the methodology of scientific inquiry, not the history of science itself. The development of rules for scientific reasoning has not been straightforward; scientific method has been the subject of intense and recurring debate throughout the history of science, and eminent natural philosophers and scientists have argued for the primacy of ...
Scientific method – body of techniques for investigating phenomena and acquiring new knowledge, as well as for correcting and integrating previous knowledge. It is based on observable , empirical , reproducible , measurable evidence , and subject to the laws of reasoning .
Multiplex assays are still more common in research than in clinical settings. [2] In a multiplex assay, microspheres of designated colors are coated with antibodies of defined binding specificities. The results can be read by flow cytometry because the beads are distinguishable by fluorescent signature. The number of analytes measured is ...
Different methodologies provide different approaches to how methods are evaluated and explained and may thus make different suggestions on what method to use in a particular case. [ 15 ] [ 11 ] According to Aleksandr Georgievich Spirkin, "[a] methodology is a system of principles and general ways of organising and structuring theoretical and ...
Analytical chemistry studies and uses instruments and methods to separate, identify, and quantify matter. [1] In practice, separation, identification or quantification may constitute the entire analysis or be combined with another method. Separation isolates analytes.