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While the mechanisms by which a formulation affects bioavailability and bioequivalence have been extensively studied in drugs, formulation factors that influence bioavailability and bioequivalence in nutritional supplements are largely unknown. [21]
Bioconcentration. In aquatic toxicology, bioconcentration is the accumulation of a water-borne chemical substance in an organism exposed to the water. [1][2] There are several ways in which to measure and assess bioaccumulation and bioconcentration. These include: octanol-water partition coefficients (K OW), bioconcentration factors (BCF ...
Copper is an essential trace element that is vital to the health of all living things (plants, animals and microorganisms). In humans, copper is essential to the proper functioning of organs and metabolic processes. Also, in humans, copper helps maintain the nervous system, immune system, brain development, and activates genes, as well as ...
Bioavailability is a function of soil properties, time, environmental conditions, and plant and microbial characteristics [7] Soil properties, such as pH, ion exchange capacity, soil organic matter content, texture and porosity influence bioavailability. Because soils with higher ion exchange and organic matter content offer more opportunities ...
Biodegradation is the breakdown of organic matter by microorganisms, such as bacteria and fungi. [a][2] It is generally assumed to be a natural process, which differentiates it from composting. Composting is a human-driven process in which biodegradation occurs under a specific set of circumstances. The process of biodegradation is threefold ...
Environmental factor. An environmental factor, ecological factor or eco factor is any factor, abiotic or biotic, that influences living organisms. [1] Abiotic factors include ambient temperature, amount of sunlight, air, soil, water and pH of the water soil in which an organism lives. Biotic factors would include the availability of food ...
ADME is the four-letter abbreviation (acronym) for absorption, distribution, metabolism, and excretion, and is mainly used in fields such as pharmacokinetics and pharmacology. The four letter stands for descriptors quantifying how a given drug interacts within body over time. The term ADME was first introduced in the 1960s, and has become a ...
Biological activity. In pharmacology, biological activity or pharmacological activity describes the beneficial or adverse effects of a drug on living matter. [1][2] When a drug is a complex chemical mixture, this activity is exerted by the substance's active ingredient or pharmacophore but can be modified by the other constituents.