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The original formula for Actifed contained pseudoephedrine hydrochloride 60 mg as the nasal decongestant and triprolidine hydrochloride 2.5 mg as the antihistamine. . However, in response to widespread laws requiring products containing pseudoephedrine to be kept behind the pharmacy counter, Pfizer changed Actifed's U.S. formula in late 2006 to contain phenylephrine HCl 10 mg as the nasal ...
The elimination half-life of pseudoephedrine on average is 5.4 hours [2] and ranges from 3 to 16 hours depending on urinary pH. [1] [11] At a pH of 5.6 to 6.0, the elimination half-life of pseudoephedrine was 5.2 to 8.0 hours. [11]
Pseudoephedrine, the decongestant found in Sudafed, is highly effective in helping people with stuffy noses breathe more easily, said Dr. Maryann Amirshahi, a medical toxicologist and a professor ...
A decongestant, or nasal decongestant, is a type of pharmaceutical drug that is used to relieve nasal congestion in the upper respiratory tract.The active ingredient in most decongestants is either pseudoephedrine or phenylephrine (the latter of which has disputed effectiveness).
[29] [30] It is also available over-the-counter in the form of 12.5 and 25 mg oral tablets for use as a bronchodilator and as a 0.5% concentration nasal spray for use as a decongestant. [30] The drug is additionally available in combination with guaifenesin in the form of oral tablets and liquids. [ 30 ]
Do over-the-counter decongestants like Sudafed PE work? Doctors have said oral phenylephrine is ineffective to relieve nasal congestion. An FDA panel will reevaluate the evidence.