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2. Targeted alpha-particle therapy - Wikipedia

   en.wikipedia.org/.../Targeted_alpha-particle_therapy

   Targeted alpha-particle therapy (or TAT) is an in-development method of targeted radionuclide therapy of various cancers. It employs radioactive substances which undergo alpha decay to treat diseased tissue at close proximity. [1] It has the potential to provide highly targeted treatment, especially to microscopic tumour cells.

3. Molecular Partners and Orano Med expand partnership to ...

   lite.aol.com/tech/story/0022/20250112/9330498.htm

   About Targeted Alpha Therapy Targeted alpha therapy (TAT) relies on a simple concept: combining the ability of biological molecules to target cancer cells with the short-range cell-killing capabilities of alpha-emitting radioisotopes. Alpha decay consists of the emission of a helium nucleus (alpha particle) together with very high linear energy ...

4. Targeted therapy - Wikipedia

   en.wikipedia.org/wiki/Targeted_therapy

   Biomarkers are usually required to aid the selection of patients who will likely respond to a given targeted therapy. [6] Co-targeted therapy involves the use of one or more therapeutics aimed at multiple targets, for example PI3K and MEK, in an attempt to generate a synergistic response [5] and prevent the development of drug resistance. [7] [8]

5. Radionuclide therapy - Wikipedia

   en.wikipedia.org/wiki/Radionuclide_therapy

   This is a type of targeted therapy which uses the physical, chemical and biological properties of the radiopharmaceutical to target areas of the body for radiation treatment. [3] The related diagnostic modality of nuclear medicine employs the same principles but uses different types or quantities of radiopharmaceuticals in order to image or ...

6. Actinium-225 - Wikipedia

   en.wikipedia.org/wiki/Actinium-225

   The decay properties of actinium-225 are favorable for usage in targeted alpha therapy (TAT); clinical trials have demonstrated the applicability of radiopharmaceuticals containing 225 Ac to treat various types of cancer. However, the scarcity of this isotope resulting from its necessary synthesis in cyclotrons limits its potential applications.

7. Radium-223 - Wikipedia

   en.wikipedia.org/wiki/Radium-223

   [5] [6] Radium-223 dichloride is an alpha particle-emitting radiotherapy drug that mimics calcium and forms complexes with hydroxyapatite at areas of increased bone turnover. [7] The principal use of radium-223, as a radiopharmaceutical to treat metastatic cancers in bone , takes advantage of its chemical similarity to calcium , and the short ...