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Environmental epigenetics is a branch of epigenetics that studies the influence of external environmental factors on the gene expression of a developing embryo. [1] The way that genes are expressed may be passed down from parent to offspring through epigenetic modifications, although environmental influences do not alter the genome itself.
Gene–environment interaction occurs when genetic factors and environmental factors interact to produce an outcome that cannot be explained by either factor alone. [6] For example, a study found that individuals carrying the genetic variant 5-HTT (the short copy) that encodes the serotonin transporter were at a higher risk of developing depression when exposed to adverse childhood experiences ...
Gene–environment interaction (or genotype–environment interaction or G×E) is when two different genotypes respond to environmental variation in different ways. A norm of reaction is a graph that shows the relationship between genes and environmental factors when phenotypic differences are continuous. [ 1 ]
Epigenetic mechanisms. In biology, epigenetics is the study of heritable traits, or a stable change of cell function, that happen without changes to the DNA sequence. [1] The Greek prefix epi-(ἐπι-"over, outside of, around") in epigenetics implies features that are "on top of" or "in addition to" the traditional (DNA sequence based) genetic mechanism of inheritance. [2]
In genetics, a maternal effect occurs when the phenotype of an organism is determined by the genotype of its mother. [1] For example, if a mutation is maternal effect recessive, then a female homozygous for the mutation may appear phenotypically normal, however her offspring will show the mutant phenotype, even if they are heterozygous for the mutation.
Twin and adoption studies have provided much of the evidence for gene–environment correlations by demonstrating that putative environmental measures are heritable. [5] For example, studies of adult twins have shown that desirable and undesirable life events are moderately heritable as are specific life events and life circumstances, including divorce, the propensity to marry, marital quality ...
The human epigenome is dynamic and can be influenced by environmental factors such as diet, stress, and toxins. The epigenome is involved in regulating gene expression, development, tissue differentiation, and suppression of transposable elements. Unlike the underlying genome, which remains largely static within an individual, the epigenome can ...
Some studies into the interaction of genetic and environmental factors in the incidence of diabetes have demonstrated that "environment-wide association studies" (EWAS, or exposome-wide association studies) may be feasible. [22] [23] However, it is not clear what data sets are most appropriate to represent the value of "E". [24]