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The Bowditch effect, also known as the Treppe phenomenon or Treppe effect or Staircase Phenomenon, [1] [2] is an autoregulation method by which myocardial tension increases with an increase in heart rate. It was first observed by Henry Pickering Bowditch in 1871.
Homeometric autoregulation occurs independently of cardiomyocyte fiber length, via the Bowditch and/or Anrep effects. [7] Via the Bowditch effect, positive inotropy occurs secondary to an increased cardiac frequency. The exact mechanism for this remains unknown, but it appears to be the result of an increased exposure of the heart to ...
Sensitizing troponin-C to the effects of calcium. Phosphorylating L-type calcium channels. This will increase their permeability to calcium, allowing more calcium into the myocyte cells, increasing contractility. An abrupt increase in afterload enhances myocardial contractility and prolongs systolic ejection time through the Anrep effect. This ...
Henry Pickering Bowditch (April 4, 1840 – March 13, 1911) was an American soldier, physician, physiologist, and dean of the Harvard Medical School. [ 1 ] [ 2 ] Following his teacher Carl Ludwig , he promoted the training of medical practitioners in a context of physiological research.
Staircase effect may refer to: Bowditch effect, arising from an increased heart rate "Jaggies", artifacts in computer graphics This page was last edited on 19 ...
Bloom (shader effect) (3D computer graphics) (demo effects) Bohr effect (hematology) (hemoproteins) (respiratory physiology) Boomerang effect (psychology) (social psychology) (psychology) Bouba/kiki effect (cognitive science) Bowditch effect (medicine)
Sleeping Beauties. Around the world a sleeping sickness plunges women into a strange, cocooned state. If awakened, they turn homicidal. King and his son screw this global story down to a small ...
The Anrep effect describes the rapid increase in myocardial contractility in response to the sudden rise in afterload, the pressure the heart must work against to eject blood. [ 1 ] [ 2 ] This adaptive mechanism allows the heart to sustain stroke volume and cardiac output despite increased resistance.