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Nucleoside reverse transcriptase translocation inhibitor (NRTTIs). [ 1 ] The antiviral effect of NRTIs and NtRTIs is essentially the same; they are analogues of the naturally occurring deoxynucleotides needed to synthesize the viral DNA and they compete with the natural deoxynucleotides for incorporation into the growing viral DNA chain.
[3] [4] Antiretroviral drugs for the treatment of HIV infections belong to six categories: Nucleoside and nucleotide reverse-transcriptase inhibitors, Non-nucleoside reverse-transcriptase inhibitors, protease inhibitors, entry inhibitors, co-receptor inhibitors and integrase inhibitors. [4] The reverse transcriptase of HIV-1 has been the main ...
Nucleoside analog reverse transcriptase inhibitors (21 P) Pages in category "Reverse transcriptase inhibitors" The following 8 pages are in this category, out of 8 total.
Pages in category "Nucleoside analog reverse transcriptase inhibitors" The following 21 pages are in this category, out of 21 total. This list may not reflect recent changes .
Islatravir is a nucleoside reverse transcriptase translocation inhibitor (NRTTI) that unlike other such inhibitors, inhibits HIV through multiple mechanisms, [8] providing rapid suppression of the virus, when tested in macaques and mice. [10] Nevertheless, there are HIV strains resistant to islatravir and research is ongoing. [11] [12]
Zalcitabine (2′-3′-dideoxycytidine, ddC), also called dideoxycytidine, is a nucleoside analog reverse-transcriptase inhibitor (NRTI) sold under the trade name Hivid. Zalcitabine was the third antiretroviral to be approved by the Food and Drug Administration (FDA) for the treatment of HIV/AIDS. It is used as part of a combination regimen.
Nucleoside reverse-transcriptase inhibitors (NRTI) and nucleotide reverse-transcriptase inhibitors (NtRTI) are nucleoside and nucleotide analogues which inhibit reverse transcription. HIV is an RNA virus, so it can not be integrated into the DNA in the nucleus of the human cell unless it is first "reverse" transcribed into DNA.
Lamivudine is a nucleoside reverse transcriptase inhibitor and works by blocking the HIV reverse transcriptase and hepatitis B virus polymerase. [1] Lamivudine was patented in 1995 and approved for use in the United States in 1995. [8] [9] It is on the World Health Organization's List of Essential Medicines. [10] It is available as a generic ...