Search results
Results From The WOW.Com Content Network
Chondrocytes (/ ˈ k ɒ n d r ə s aɪ t,-d r oʊ-/, [1] from Greek χόνδρος (chondros) 'cartilage' and κύτος (kytos) 'cell') are the only cells found in healthy cartilage. They produce and maintain the cartilaginous matrix, which consists mainly of collagen and proteoglycans .
The cartilage cells or chondrocytes are contained in cavities in the matrix, called cartilage lacunae; around these, the matrix is arranged in concentric lines as if it had been formed in successive portions around the cartilage cells. This constitutes the so-called capsule of the space.
Cartilage gives the structures a definite but pliable form, making them strong, but with limited mobility and flexibility. [2] [3] Cartilage has no nerves. [2] Hyaline cartilage also forms the temporary embryonic skeleton, which is gradually replaced by bone, and the skeleton of elasmobranch fish. [citation needed]
Chondroblasts are called chondrocytes when they embed themselves in the cartilage matrix, consisting of proteoglycan and collagen fibers, until they lie in the matrix lacunae. Once they embed themselves into the cartilage matrix, they grow the cartilage matrix by growing more cartilage extracellular matrix rather than by dividing further.
In embryogenesis, the skeletal system is derived from the mesoderm germ layer. Chondrification (also known as chondrogenesis) is the process by which cartilage is formed from condensed mesenchyme tissue, which differentiates into chondroblasts and begins secreting the molecules (aggrecan and collagen type II) that form the extracellular matrix.
Chondrocytes multiply and form trebeculae. Cartilage is progressively eroded and replaced by hardened bone, extending towards the epiphysis . A perichondrium layer surrounding the cartilage forms the periosteum , which generates osteogenic cells that then go on to make a collar that encircles the outside of the bone and remodels the medullary ...
In this zone, the chondrocytes undergo hypertrophy (become enlarged). Chondrocytes contain large amounts of glycogen and begin to secrete vascular endothelial growth factor to initiate vascular invasion. Zone of calcification In this zone, chondrocytes are either dying or dead, leaving cavities that will later become invaded by bone-forming ...
You are free: to share – to copy, distribute and transmit the work; to remix – to adapt the work; Under the following conditions: attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made.