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Common over-the-counter medicines that can cause headaches when overused include Excedrin Migraine, Cafergot, and Advil. [ 11 ] [ 12 ] Dietary and medicinal caffeine consumption appears to be a modest risk factor for chronic daily headache onset, regardless of headache type.
The combination was first introduced as the name Trigesic, as the formula of 125 mg paracetamol, 230 mg aspirin, and 30 mg caffeine, in July 1950 by Squibb, which is now Bristol Myers Squibb, but was recalled in the following year due to several reports that the drug might cause blood dyscrasia. [5]
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The new FDA warning urges caution in medications containing more than 325 mg of acetaminophen, with a recommended daily limit of 4,000 mg. For reference, a single tablet of Extra Strength Tylenol ...
It was also an ingredient in the over-the-counter pain remedy BC Powder but was removed from the formulation in 2009, and Excedrin used the ingredient from 1960 to 1980 in conjunction with aspirin, acetaminophen, and caffeine. It was used in later formulations of Vincent's powders in Australia as a substitute for phenacetin.
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2003: Excedrin Tension Headache contains 500 mg acetaminophen, and 65 mg caffeine. 2005: Excedrin Sinus Headache contains 325 mg acetaminophen and 5 mg phenylephrine HCl as a decongestant. 2007: Excedrin Back and Body – a dual-ingredient formula claiming that it "works two ways—as a pain reliever and a pain blocker right where it hurts".
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