Search results
Results From The WOW.Com Content Network
The tert-butyloxycarbonyl protecting group or tert-butoxycarbonyl protecting group [1] (BOC group) is an acid-labile protecting group used in organic synthesis. The BOC group can be added to amines under aqueous conditions using di- tert -butyl dicarbonate in the presence of a base such as sodium hydroxide :
Di-tert-butyl dicarbonate is a reagent widely used in organic synthesis. [1] Since this compound can be regarded formally as the acid anhydride derived from a tert-butoxycarbonyl (Boc) group, it is commonly referred to as Boc anhydride. This pyrocarbonate reacts with amines to give N-tert-butoxycarbonyl or so-called Boc
Ethylene glycol protects a ketone (as an acetal) during an ester reduction, vs. unprotected reduction to a diol. A protecting group or protective group is introduced into a molecule by chemical modification of a functional group to obtain chemoselectivity in a subsequent chemical reaction.
tert-Butoxycarbonyl, abbreviated as "Boc", "BOC" or "t-Boc", a protecting group used in organic chemistry; Banks: Bank of Canada, Canada's central bank; Bank of Ceylon, a major government-owned commercial bank in Sri Lanka; Bank of China, a major state-owned bank in the People's Republic of China; Bank of Cyprus, a major Cypriot financial ...
For example, when carried out in the presence of tert-butanol, the reaction generates Boc-protected amines, useful intermediates in organic synthesis. [ 24 ] [ 25 ] Likewise, when the Curtius reaction is performed in the presence of benzyl alcohol , Cbz -protected amines are formed.
TFA is used as a strong acid to remove protecting groups such as Boc used in organic chemistry and peptide synthesis. [8] [9] At a low concentration, TFA is used as an ion pairing agent in liquid chromatography of organic compounds, particularly peptides and small proteins.
The fluorenylmethoxycarbonyl protecting group (Fmoc) is a base-labile amine protecting group used in organic synthesis, particularly in peptide synthesis [1]. It is popular for its stability toward acids and hydrolysis and its selective removal by weak bases, such as piperidine , without affecting most other protecting groups or sensitive ...
In organic chemistry, there can be more than one chemical compound with the same composition and molecular weight. Generally, these are called isomers. Isomers usually have substantially different chemical properties, and often may be isolated without spontaneously interconverting. A common example is glucose vs. fructose.