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Lisinopril/hydrochlorothiazide, sold under the brand name Zestoretic among others, is a fixed-dose combination medication used for the treatment of high blood pressure (hypertension). [2] It contains lisinopril , an ACE inhibitor , and hydrochlorothiazide , a diuretic .
Lisinopril leaves the body completely unchanged in the urine. [1] [16] The half-life of lisinopril is 12 hours, and is increased in people with kidney problems. [1] [16] While the plasma half-life of lisinopril has been estimated between 12 and 13 hours, the elimination half-life is much longer, at around 30 hours. [18]
Enalapril/hydrochlorothiazide (trade name Enalapril comp), wherein enalapril is the ACE inhibitor and hydrochlorothiazide is the thiazide. Quinapril/hydrochlorothiazide (trade name Accuretic) [2] Lisinopril/hydrochlorothiazide is marketed as Prinzide, [3] Zestoretic, [4] and many others.
Hydrochlorothiazide, sold under the brand name Hydrodiuril among others, is a diuretic medication used to treat hypertension and swelling due to fluid build-up. [4] Other uses include treating diabetes insipidus and renal tubular acidosis and to decrease the risk of kidney stones in those with a high calcium level in the urine . [ 4 ]
Angiotensin-converting-enzyme inhibitors (ACE inhibitors) are a class of medication used primarily for the treatment of high blood pressure and heart failure. [1] [2] This class of medicine works by causing relaxation of blood vessels as well as a decrease in blood volume, which leads to lower blood pressure and decreased oxygen demand from the heart.
Lisinopril/amlodipine, sold under the brand name Lisonorm among others, is a medication used to treat high blood pressure. [1] It is a combination of lisinopril an ACE inhibitor with amlodipine a calcium channel blocker. [1] It may be used when blood pressure is not well controlled with each of the two agents alone. [4] It is taken by mouth. [1]
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[2] [3] It decreases blood pressure mainly by hydrochlorothiazide while triamterene decreases the amount of potassium lost. [2] [3] The combination was approved for medical use in the United States in 1965. [5] In 2022, it was the 116th most commonly prescribed medication in the United States, with more than 5 million prescriptions. [6] [7]