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Amiodarone is an antiarrhythmic medication used to treat and prevent a number of types of cardiac dysrhythmias. [4] ... Contraindications of amiodarone also include:
Compounds that prolong the action potential: matching the modern classification, with the key drug example being amiodarone, and a surgical example being thyroidectomy. This was not a defining characteristic in an earlier review by Charlier et al. (1968), [ 17 ] but was supported by experimental data presented by Vaughan Williams (1970).
Amiodarone induced thyrotoxicosis (AIT) is a form of hyperthyroidism due to treatment with antiarrhythmic drug, amiodarone. Amiodarone induced thyroid dysfunction more commonly results in hypothyroidism , estimated to occur in 6-32% of patients, whereas hyperthyroidism from amiodarone use is estimated at 1-12%. [ 1 ]
Amiodarone in atrial fibrillation with WPW, is linked to ventricular fibrillation, and thus may be worse than procainamide. [ 7 ] AV node blockers should be avoided in atrial fibrillation and atrial flutter with WPW or history of it; this includes adenosine , diltiazem , verapamil , other calcium channel blockers , and beta blockers . [ 25 ]
Amiodarone is also safe to use in individuals with cardiomyopathy and atrial fibrillation, to maintain normal sinus rhythm. Amiodarone prolongation of the action potential is uniform over a wide range of heart rates, so this drug does not have reverse use-dependent action. Amiodarone was the first agent described in this class. [4]
Contraindications. Patients with aortic stenosis, ... which was adopted in 2000 in an attempt to avoid confusion with amiodarone. [13] Synthesis
A full list of drug interactions with flecainide can be obtained from the manufacturer. Some important drug interactions with flecainide include: [citation needed] Alcohol – may further depress normal heart function; Amiodarone – inhibits cytochrome P450 2D6 and may increase flecainide levels
The effect was first discovered accidentally in 1989, when a test of drug interactions with alcohol used grapefruit juice to hide the taste of the ethanol. [ 9 ] [ 10 ] A 2005 medical review advised patients to avoid all citrus juices until further research clarifies the risks. [ 11 ]