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But systems like it “have great potential to be used by vaccine manufacturers for the design of variant-proof vaccines,” by pointing out target regions of the virus unlikely to mutate in the ...
Predict was launched in 2009 in response to the influenza A virus subtype H5N1 "bird flu" outbreak in 2005. It was designed and overseen by Dennis Carroll, then the director of the USAID emerging threats division, [2] with epidemiologist Jonna Mazet of the University of California, Davis, as its global director. [3]
Datahub Novel Coronavirus 2019 dataset [70] [71] - COVID-19 dataset Coronavirus disease 2019 (COVID-19) time series listing confirmed cases, reported deaths and reported recoveries. Impfdashboard.de - Germany's vaccination monitor [72] Simulation der COVID19-Impfkampagne [73] - Monitor for vaccination-campaign in Germany by Zi Data Science Lab
The Eterna Open-Vaccine project allows video game players to "design an mRNA encoding a potential vaccine against the novel coronavirus." [50] The EU-Citizen Science project provides "a selection of resources related to the current COVID-19 pandemic. It contains links to citizen science and crowdsourcing projects." [51]
Although the quality and quantity of antibody production by a potential vaccine is intended to neutralize the COVID‑19 infection, a vaccine may have an unintended opposite effect by causing antibody-dependent disease enhancement (ADE), which increases the virus attachment to its target cells and might trigger a cytokine storm if a vaccinated ...
Following warnings and increased preparedness in the 2000s, the 2009 swine flu pandemic led to rapid anti-pandemic reactions amongst the Western countries. The H1N1/09 virus strain with mild symptoms and low lethality eventually led to a backlash over public sector over-reactiveness, spending, and the high cost of the 2009 flu vaccine.
Evidence from vaccine use during the pandemic shows vaccination can reduce infection and is most effective at preventing severe COVID-19 symptoms and death, but is less good at preventing mild COVID-19. Efficacy wanes over time but can be maintained with boosters. [398]
[225] [226] It is unclear whether vaccines can play a role in pandemic prevention alongside pandemic mitigation. Nathan Wolfe proposes that pathogen detection and prediction may allow establishing viral libraries before novel epidemics emerge – substantially decreasing the time to develop a new vaccine. [213]