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A significant amount of research has been performed on glycosaminoglycans, especially glucosamine and chondroitin, for the treatment of arthritis.These compounds are commonly marketed as nutritional supplements and numerous 'soft therapeutic claims' are made about their health benefits - especially in aging populations. [1]
[5] [32] Subjects were randomly assigned to one of five orally administered treatments: two 250 mg capsules of glucosamine hydrochloride three times daily, two 200 mg capsules of chondroitin sulfate three times daily, two capsules of 250 mg of glucosamine hydrochloride plus 200 mg of chondroitin sulfate three times daily, 200 mg of celecoxib ...
Glucosamine is often sold in combination with other supplements such as chondroitin sulfate and methylsulfonylmethane. [ citation needed ] Glucosamine, along with commonly used chondroitin, is not routinely prescribed to treat people who have symptomatic osteoarthritis of the knee, as there is insufficient evidence that this treatment is helpful.
Methylsulfonylmethane is marketed as a dietary supplement with medical claims ranging from anti-inflammatory effects for pain management, skin condition and aging treatments, and immune system modulation. [9] [10] [11] No medical uses for MSM have been approved and there is limited evidence to support most of the claims.
Distinguished from chondroitin sulfate by the presence of iduronic acid, although some hexuronic acid monosaccharides may be glucuronic acid. [16] Keratan sulfate: Gal or Gal(6S) GlcNAc or GlcNAc(6S)-Gal(6S)β1-4GlcNAc(6S)β1-3: Keratan sulfate type II may be fucosylated. [21] Heparin: GlcUA or IdoUA(2S) GlcNAc or GlcNS or GlcNAc(6S) or GlcNS(6S)
Chondroitin sulfate proteoglycans (CSPGs) are proteoglycans consisting of a protein core and a chondroitin sulfate side chain. They are known to be structural components of a variety of human tissues, including cartilage , and also play key roles in neural development and glial scar formation.
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