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Chromium toxicity refers to any poisonous toxic effect in an organism or cell that results from exposure to specific forms of chromium—especially hexavalent chromium. [1] Hexavalent chromium and its compounds are toxic when inhaled or ingested. Trivalent chromium is a trace mineral that is essential to human nutrition.
Chromium was once proposed as an essential nutrient in maintaining normal blood glucose levels, [6] but this function has not been sufficiently demonstrated. [ 1 ] [ 2 ] The European Food Safety Authority concluded that there is no convincing evidence to show chromium as an essential nutrient, thereby not justifying the setting of ...
Kidney toxicity [5] associated with kidney failure; associated with development of cancer, particularly of the urinary tract, known carcinogen [8] [9] Atractylate Atractylis gummifera: Liver damage, [3] nausea, vomiting, epigastric and abdominal pain, diarrhoea, anxiety, headache and convulsions, often followed by coma [10]
Chromium, especially hexavalent chromium, is highly toxic to fish because it is easily absorbed across the gills, readily enters blood circulation, crosses cell membranes and bioconcentrates up the food chain. In contrast, the toxicity of trivalent chromium is very low, attributed to poor membrane permeability and little biomagnification. [141]
The river water was contaminated with toxic metals including arsenic, copper, barium, cadmium, chromium, lead, mercury, nickel, and thallium. [2] Cleanup costs may exceed $1.2 billion. [3] A toxic heavy metal is a common but misleading term for a metal-like element noted for its potential toxicity. [4]
Chromium deficiency is described as the consequence of an insufficient dietary intake of the mineral chromium.Chromium was first proposed as an essential element for normal glucose metabolism in 1959, [1] but its biological function has not been identified. [2]
Nephrotoxicity is toxicity in the kidneys. It is a poisonous effect of some substances, both toxic chemicals and medications, on kidney function. [1] There are various forms, [2] and some drugs may affect kidney function in more than one way. Nephrotoxins are substances displaying nephrotoxicity.
Indium salts are toxic if more than few milligrams are ingested and will affect the kidneys, liver, and heart. [93] Cisplatin (PtCl 2 (NH 3) 2), an important drug used to kill cancer cells, is also a kidney and nerve poison. [82]