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Infectious mononucleosis (IM, mono), also known as glandular fever, is an infection usually caused by the Epstein–Barr virus (EBV). [2] [3] Most people are infected by the virus as children, when the disease produces few or no symptoms. [2] In young adults, the disease often results in fever, sore throat, enlarged lymph nodes in the neck, and ...
In 1967, a technician in their laboratory developed mononucleosis and they were able to compare a stored serum sample, showing that antibodies to the virus developed. [ 77 ] [ 79 ] [ 80 ] In 1968, they discovered that EBV can directly immortalize B cells after infection, [ 43 ] mimicking some forms of EBV-related infections, [ 78 ] and ...
Nil Filatov is most famous for describing infectious mononucleosis (also known as Filatov's disease) in 1887 and Dukes' disease (sometimes referred as Dukes-Filatov disease) in 1885; he was also one of the first to observe Koplik's spots (1895). In cooperation with Georgy Gabrichevsky he introduced serumal treatment of diphtheria in 1894.
The disease develops as a complication or progression of either Epstein–Barr virus-positive infectious mononucleosis (EPV+ IM) or chronic active Epstein–Barr virus infection (CAEBV)., [1] that is, as a worsening of the signs/symptoms some three weeks after the onset of an EBV+ IM-like disease or an any time during the course of CAEBV.
There are several forms of Epstein–Barr virus (EBV) infection. These include asymptomatic infections, the primary infection, infectious mononucleosis, and the progression of asymptomatic or primary infections to: 1) any one of various Epstein–Barr virus-associated lymphoproliferative diseases such as chronic active EBV infection, EBV+ hemophagocytic lymphohistiocytosis, Burkitt's lymphoma ...
The mononuclear spot test or monospot test, a form of the heterophile antibody test, [1] is a rapid test for infectious mononucleosis due to Epstein–Barr virus (EBV). It is an improvement on the Paul–Bunnell test. [2] The test is specific for heterophile antibodies produced by the human immune system in response to EBV infection.
James Corson Niederman (November 27, 1924 – March 2, 2024) was an American epidemiologist whose research identified the Epstein–Barr virus as the cause of infectious mononucleosis in a study published in 1968. [1] [2]
Emil Pfeiffer (1 March 1846 – 13 July 1921) was a German physician and pediatrician.. He studied medicine at the universities of Bonn, Würzburg, and Berlin.It was at Berlin where he received his doctorate in 1869.