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12266 Ensembl ENSG00000125730 ENSMUSG00000024164 UniProt P01024 P01027 RefSeq (mRNA) NM_000064 NM_009778 RefSeq (protein) NP_000055 NP_033908 Location (UCSC) Chr 19: 6.68 – 6.73 Mb Chr 17: 57.51 – 57.54 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Complement component 3, often simply called C3, is a protein of the immune system that is found primarily in the blood. It plays a ...
A variety of tests can be used to measure TCA, but the most commonly used on is the CH50 test. [1] [2] Other tests include the liposome immunoassay (LIA), [3] single tube titration method, [4] and the plate-hemolysis method. [5]
As mentioned before, there are no external indications of properdin deficiency, and as such, properdin deficiency can only be reliably detected by lab tests. [3] The typical tests for complement deficiencies, such as the measurement of C3 and C4, do not detect low levels of the absence of properdin. [2]
The cleavage of the C4 results in C4b bearing a thioester functional group [-S-C(O)-]: work in the 1980s on C3, and then on C4, indicated the presence, within the parent C3 and C4 structures, of a unique protein modification, a 15-atom (15-membered) thionolactone ring serving to connect the thiol side chain of the amino acid cysteine (Cys) in a ...
C3: In terms of deficiency of C3, it has been found that 17 mutations in the C3 gene cause problems with C3. This rare condition mutates or prevents C3 protein from forming, lowering the immune system's ability to protect. [17] C4: C4 deficiency is highly associated with systemic lupus erythematosus. [3]
Initial complement tests often include C3 and C4, but not C5 through C9. Instead, the CH50 result may play a role in diagnosis: if the CH50 level is low but C3 and C4 are normal, then analysis of the individual terminal components may be warranted.
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