Ads
related to: phages to treat bacterial infections
Search results
Results From The WOW.Com Content Network
Phage therapy is the use of bacteriophages to treat bacterial infections. Bacteriophage treatment offers a possible alternative to conventional antibiotic treatments for bacterial infection. [55] It is conceivable that, although bacteria can develop resistance to phages, the resistance might be easier to overcome than resistance to antibiotics.
George Eliava pioneered the use of phages in treating bacterial infections. Phages were discovered to be antibacterial agents and were used in the former Soviet Republic of Georgia (pioneered there by Giorgi Eliava with help from the co-discoverer of bacteriophages, Félix d'Hérelle) during the 1920s and 1930s for treating bacterial infections.
Phage therapy is the method by which bacteriophages (viruses which infect bacteria) are used to treat bacterial infections or reduce bacterial populations. Phage therapy has gained recent attention in the United States as an alternative to standard antibiotic therapy .
The bacteria are infected with phages and die, producing new phages; the medium clears. The medium is filtered through porcelain filter, holding back bacteria and larger objects; only the smaller phages pass through. In early 1919, d'Hérelle isolated phages from chicken feces, successfully treating a plague of chicken typhoid with them. [13]
Mycobacteriophage Bxb1 Structure [1]. A mycobacteriophage is a member of a group of bacteriophages known to have mycobacteria as host bacterial species. While originally isolated from the bacterial species Mycobacterium smegmatis and Mycobacterium tuberculosis, [2] the causative agent of tuberculosis, more than 4,200 mycobacteriophage species have since been isolated from various environmental ...
Filamentous phages, unlike most other phages, are continually extruded through the bacterial membrane without killing the host. [19] Genetic studies on M13 using conditional lethal mutants, initiated by David Pratt and colleagues, led to description of phage gene functions.
M13 is one of the Ff phages (fd and f1 are others), a member of the family filamentous bacteriophage ().Ff phages are composed of circular single-stranded DNA (), which in the case of the m13 phage is 6407 nucleotides long and is encapsulated in approximately 2700 copies of the major coat protein p8, and capped with about 5 copies each of four different minor coat proteins (p3 and p6 at one ...
Fischetti is known for his role as the "father" of phage lysins as therapeutics, with his laboratory being the first to use phage lysins in animal models to prevent and treat infections. [ 27 ] [ 28 ] [ 29 ] His studies on the M protein of Streptococcus pyogenes also revealed basic discoveries on the way surface proteins on gram-positive ...