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Voltage-gated sodium channels (VGSCs), also known as voltage-dependent sodium channels (VDSCs), are a group of voltage-gated ion channels found in the membrane of excitable cells (e.g., muscle, glial cells, neurons, etc.) with a permeability to the sodium ion Na +. They are the main channels involved in action potential of excitable cells.
The family of sodium channels has 9 known members, with amino acid identity >50% in the trans-membrane segments and extracellular loop regions. A standardized nomenclature for sodium channels is currently used and is maintained by the IUPHAR. [11] The proteins of these channels are named Na v 1.1 through Na v 1.9.
The SCN1A gene codes for the alpha subunit of the voltage-gated sodium ion channel making it a member of ten paralogous gene families which code for the voltage-gated sodium transmembrane proteins Na V 1.1. Within the family of genes which code for other portions of voltage-gated sodium channels, the SCN1A mutations were the first identified ...
The epithelial sodium channel (ENaC), (also known as amiloride-sensitive sodium channel) is a membrane-bound ion channel that is selectively permeable to sodium ions (Na +).It is assembled as a heterotrimer composed of three homologous subunits α or δ, β, and γ, [2] These subunits are encoded by four genes: SCNN1A, SCNN1B, SCNN1G, and SCNN1D.
6338 20277 Ensembl ENSG00000168447 ENSMUSG00000030873 UniProt P51168 Q9WU38 RefSeq (mRNA) NM_000336 NM_001272023 NM_011325 RefSeq (protein) NP_000327 NP_001258952 NP_035455 Location (UCSC) Chr 16: 23.28 – 23.38 Mb Chr 7: 121.46 – 121.52 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse The SCNN1B gene encodes for the β subunit of the epithelial sodium channel ENaC in vertebrates ...
Sodium channel protein type 2 subunit alpha, is a protein that in humans is encoded by the SCN2A gene. [5] Functional sodium channels contain an ion conductive alpha subunit and one or more regulatory beta subunits. Sodium channels which contain sodium channel protein type 2 subunit alpha are sometimes called Na v 1.2 channels.
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Sodium channel, voltage-gated, type XI, alpha subunit also known as SCN11A or Na v 1.9 is a voltage-gated sodium ion channel protein which is encoded by the SCN11A gene on chromosome 3 in humans. [ 5 ] [ 6 ] Like Na v 1.7 and Na v 1.8 , Na v 1.9 plays a role in pain perception.