Search results
Results From The WOW.Com Content Network
The family of sodium channels has 9 known members, with amino acid identity >50% in the trans-membrane segments and extracellular loop regions. A standardized nomenclature for sodium channels is currently used and is maintained by the IUPHAR. [11] The proteins of these channels are named Na v 1.1 through Na v 1.9.
Sodium channel protein type 2 subunit alpha, is a protein that in humans is encoded by the SCN2A gene. [5] Functional sodium channels contain an ion conductive alpha subunit and one or more regulatory beta subunits. Sodium channels which contain sodium channel protein type 2 subunit alpha are sometimes called Na v 1.2 channels.
In hypokalemic periodic paralysis, arginine residues making up the voltage sensor of Na v 1.4 are mutated. The voltage sensor comprises the S4 alpha helix of each of the four transmembrane domains (I-IV) of the protein, and contains basic residues that only allow entry of the positive sodium ions at appropriate membrane voltages by blocking or opening the channel pore.
Voltage-gated sodium channels (VGSCs), also known as voltage-dependent sodium channels (VDSCs), are a group of voltage-gated ion channels found in the membrane of excitable cells (e.g., muscle, glial cells, neurons, etc.) with a permeability to the sodium ion Na +. They are the main channels involved in action potential of excitable cells.
The SCN1A gene codes for the alpha subunit of the voltage-gated sodium ion channel making it a member of ten paralogous gene families which code for the voltage-gated sodium transmembrane proteins Na V 1.1. Within the family of genes which code for other portions of voltage-gated sodium channels, the SCN1A mutations were the first identified ...
Sodium channel protein type 5 subunit alpha, also known as Na V 1.5 is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. Na V 1.5 is found primarily in cardiac muscle, where it mediates the fast influx of Na +-ions (I Na) across the cell membrane, resulting in the fast depolarization phase of the cardiac action potential.
Sodium channel, voltage-gated, type XI, alpha subunit also known as SCN11A or Na v 1.9 is a voltage-gated sodium ion channel protein which is encoded by the SCN11A gene on chromosome 3 in humans. [ 5 ] [ 6 ] Like Na v 1.7 and Na v 1.8 , Na v 1.9 plays a role in pain perception.
The epithelial sodium channel (ENaC), (also known as amiloride-sensitive sodium channel) is a membrane-bound ion channel that is selectively permeable to sodium ions (Na +).It is assembled as a heterotrimer composed of three homologous subunits α or δ, β, and γ, [2] These subunits are encoded by four genes: SCNN1A, SCNN1B, SCNN1G, and SCNN1D.