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Salicin, a glycoside related to aspirin Chemical structure of oleandrin, a cardiac glycoside. In chemistry, a glycoside / ˈ ɡ l aɪ k ə s aɪ d / is a molecule in which a sugar is bound to another functional group via a glycosidic bond. Glycosides play numerous important roles in living organisms. Many plants store chemicals in the form of ...
Human lysosomal α-glucosidase has been studied for the significance of the Asp-518 and other residues in proximity of the enzyme's active site. It was found that substituting Asp-513 with Glu-513 interferes with posttranslational modification and intracellular transport of α-glucosidase's precursor.
In humans, tissues within the liver, small intestine, spleen and kidney contain a cytosolic β-glucosidase (CBG) that hydrolyses various β-d-glycosides. This human enzyme shows significant activity towards many xenobiotics commonly found in the human diet including glycosides of phytoestrogens, flavonoids, simple phenolics and cyanogens and ...
Alpha-glucosidases are enzymes involved in breaking down complex carbohydrates such as starch and glycogen into their monomers. [2]They catalyze the cleavage of individual glucosyl residues from various glycoconjugates including alpha- or beta-linked polymers of glucose.
Cardiac glycosides are a class of organic compounds that increase the output force of the heart and decrease its rate of contractions by inhibiting the cellular sodium-potassium ATPase pump. [1] Their beneficial medical uses include treatments for congestive heart failure and cardiac arrhythmias ; however, their relative toxicity prevents them ...
This enzyme is a part of a family of enzymes called glycoside hydrolase family 31 (GH31). This is due to the digestive mechanism of the enzyme. GH31 enzymes undergo what is known as the Koshland double displacement mechanism [11] in which a glycosylation and deglycosylation step occurs, resulting in the retention of the overall configuration of the anomeric center.
14387 Ensembl ENSG00000171298 ENSMUSG00000025579 UniProt P10253 P70699 RefSeq (mRNA) NM_000152 NM_001079803 NM_001079804 NM_001159324 NM_008064 RefSeq (protein) NP_000143 NP_001073271 NP_001073272 NP_001152796 NP_032090 Location (UCSC) Chr 17: 80.1 – 80.12 Mb Chr 11: 119.16 – 119.18 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Acid alpha-glucosidase, also called acid maltase ...
Digitoxin is a cardiac glycoside used for the treatment of heart failure and certain kinds of heart arrhythmia. It is a phytosteroid and is similar in structure and effects to digoxin, though the effects are longer-lasting. Unlike digoxin, which is eliminated from the body via the kidneys, it is eliminated via the liver, and so can be used in ...