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The retinoblastoma protein (protein name abbreviated Rb or pRb; gene name abbreviated Rb, RB or RB1) is a tumor suppressor protein that is dysfunctional in several major cancers. [5] One function of pRb is to prevent excessive cell growth by inhibiting cell cycle progression until a cell is ready to divide.
Retinoblastoma (Rb) is a rare form of cancer that rapidly develops from the immature cells of a retina, [2] the light-detecting tissue of the eye. [3] It is the most common primary malignant intraocular cancer in children, and 80% of retinoblastoma cases are first detected in those under 3 years old.
Retinopathy of prematurity (ROP), also called retrolental fibroplasia (RLF) and Terry syndrome, is a disease of the eye affecting prematurely born babies generally having received neonatal intensive care, in which oxygen therapy is used because of the premature development of their lungs. [2]
The retinoblastoma tumor suppressor (pRB) protein binds with many other proteins. In various human cancers, pRB suppresses cellular proliferation and is inactivated. Cell cycle-dependent phosphorylation regulates the activity of pRB. This gene encodes a protein which binds to underphosphorylated but not phosphorylated pRB.
Leukocoria is a medical sign for a number of conditions, including Coats disease, congenital cataract, corneal scarring, melanoma of the ciliary body, [2] Norrie disease, ocular toxocariasis, persistence of the tunica vasculosa lentis (PFV/PHPV), retinoblastoma, and retrolental fibroplasia.
Infants less than 6 months old will almost always show symptoms that can include irritability, decreased activity, decreased appetite and apnea (breathing that stops and starts). Fever is ...
From symptoms to treatment options, these are the need-to-know facts on RSV according to experts. Respiratory syncytial virus, or RSV, can lead to dangerous infections in young babies, yet it's ...
The following year, Gallie was named a Member of the Order of Canada for her "contributions to the prevention, diagnosis and treatment of retinoblastoma, a childhood eye cancer." [ 7 ] She was also recognized with the 2018 Helen Keller Prize for Vision Research [ 8 ] and the 2019 Collaborative Leadership Research Grant from the non-profit ...