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Retinoblastoma (Rb) is a rare form of cancer that rapidly develops from the immature cells of a retina, [2] the light-detecting tissue of the eye. [3] It is the most common primary malignant intraocular cancer in children, and 80% of retinoblastoma cases are first detected in those under 3 years old.
The retinoblastoma protein (protein name abbreviated Rb or pRb; gene name abbreviated Rb, RB or RB1) is a tumor suppressor protein that is dysfunctional in several major cancers. [5] One function of pRb is to prevent excessive cell growth by inhibiting cell cycle progression until a cell is ready to divide.
[2] [3] However, only about 10% of children diagnosed with cancer reside in high-income countries where the necessary treatments and care is available. [4] [5] Childhood cancer represents only about 1% of all types of cancers diagnosed in children and adults, but it is often more complex than adult cancers with unique biological characteristics ...
Brief resolved unexplained event (BRUE), previously apparent life-threatening event (ALTE), is a medical term in pediatrics that describes an event that occurs during infancy. The event is noted by an observer, typically the infant's caregiver.
She was also named a Member of the Order of Ontario for being an expert in the treatment of retinoblastoma and contributing to the health care of Canadians. [ 4 ] In 2013, Gallie led a research team that discovered a new and potentially less life-threatening form of retinoblastoma. [ 6 ]
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This is an accepted version of this page This is the latest accepted revision, reviewed on 11 February 2025. Neoplasm in the brain Medical condition Brain tumor Other names Intracranial neoplasm, brain tumour, brain cancer Brain metastasis in the right cerebral hemisphere from lung cancer, shown on magnetic resonance imaging Specialty Neurosurgery, neuro-oncology Symptoms Vary depending on the ...
Infants less than 6 months old will almost always show symptoms that can include irritability, decreased activity, decreased appetite and apnea (breathing that stops and starts). Fever is ...