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Hyposplenism is used to describe reduced ('hypo-') splenic functioning, but not as severely affected as with asplenism. Functional asplenia occurs when splenic tissue is present but does not work well (e.g. sickle-cell disease, polysplenia) – such patients are managed as if asplenic – while in anatomic asplenia, the spleen itself is absent.
The spleen is an organ within the lymphatic system and its primary function is to filter blood. However, the spleen also plays a key role in immune responses as it detects pathogens within the blood and secretes phagocytes to fight potential infection. Without these immune functions, individuals with isolated congenital asplenia are extremely ...
The spleen is an important immunological organ that acts as a filter for red blood cells, triggers phagocytosis of invaders, and mounts an immunological response when necessary. [2] Lack of a spleen, called asplenia, can occur by autosplenectomy or the surgical counterpart, splenectomy. Asplenia can increase susceptibility to infection. [3]
Felty's syndrome (FS), also called Felty syndrome, [1] is a rare autoimmune disease characterized by the triad of rheumatoid arthritis, enlargement of the spleen and low neutrophil count. The condition is more common in those aged 50–70 years, specifically more prevalent in females than males, and more so in Caucasians than those of African ...
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The Centers for Disease Control and Prevention's annual vaccine recommendations includes specifics for individuals without a functioning spleen. [ 11 ] The Green Book (immunisation guidance, UK) in chapter 7 [ 12 ] covers immunisation of people with underlying medical conditions that affect immunity which includes asplenic patients.
An image of the spleen in the human body. Also shows the red and white pulp regions. Splenocytes are spleen cells and consist of leukocytes like B and T cells, dendritic cells, and macrophages. [2] The spleen is split into red and white pulp regions with the marginal zone separating the two areas. The red pulp is involved with filtering blood ...
Partial splenectomy: Since the spleen is important for protecting against encapsulated organisms, sepsis caused by encapsulated organisms is a possible complication of splenectomy. [7] The option of partial splenectomy may be considered in the interest of preserving immune function. Research on outcomes is currently limited, [7] but favorable. [8]