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The drug is also under investigation as an antidepressant and for the treatment of neuropathic pain. It is related in chemical structure to venlafaxine. Due to being an opioid, there is risk of abuse and addiction, but it does have less abuse potential, respiratory depression, and constipation compared to other opioids (hydrocodone, oxycodone ...
The comparative efficacy of duloxetine and established pain-relief medications for diabetic peripheral neuropathy is unclear. A systematic review noted that tricyclic antidepressants ( imipramine and amitriptyline ), traditional anticonvulsants and opioids have better efficacy than duloxetine.
In addition to post-treatment relapse, depressive symptoms can even recur in the course of long-term therapy (tachyphylaxis). Also, currently available antidepressants all elicit undesirable side-effects, and new agents should be divested of the distressing side-effects of both first and second-generation antidepressants. [6]
Antidepressants are recommended as an alternative or additional first step to self-help programs in the treatment of bulimia nervosa. [37] SSRIs (fluoxetine in particular) are preferred over other anti-depressants due to their acceptability, tolerability, and superior reduction of symptoms in short-term trials.
Existing guidelines say the drugs may help with quality of life, pain, sleep and psychological distress. Skip to main content. 24/7 Help. For premium support please call: 800-290-4726 ...
A level between 50 and 150 ng/mL of nortriptyline in the blood generally corresponds with an antidepressant effect. [12] It is also used off-label for the treatment of panic disorder, ADHD, irritable bowel syndrome, tobacco-cessation, migraine prophylaxis and chronic pain or neuralgia modification, particularly temporomandibular joint disorder.
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