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5957 19674 Ensembl ENSG00000109047 ENSMUSG00000020907 UniProt P35243 P34057 RefSeq (mRNA) NM_002903 NM_009038 RefSeq (protein) NP_002894 NP_033064 Location (UCSC) Chr 17: 9.9 – 9.91 Mb Chr 11: 67.59 – 67.59 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Recoverin is a 23 kilodalton (kDa) neuronal calcium-binding protein that is primarily detected in the photoreceptor cells of ...
A photoreceptor cell is a specialized type of neuroepithelial cell found in the retina that is capable of visual phototransduction. The great biological importance of photoreceptors is that they convert light (visible electromagnetic radiation ) into signals that can stimulate biological processes.
In advanced stages of AMD, atrophy of the RPE (geographic atrophy) and/or development of new blood vessels (neovascularization) result in the death of photoreceptors and central vision loss. [citation needed] In the dry (nonexudative) form, drusen accumulate between the retina and the choroid, causing atrophy and scarring to the retina. In the ...
Fundus of geographic atrophy. Geographic atrophy (GA), also known as atrophic age-related macular degeneration (AMD) or advanced dry AMD, is an advanced form of age-related macular degeneration that can result in the progressive and irreversible loss of retinal tissue (photoreceptors, retinal pigment epithelium, choriocapillaris) which can lead to a loss of central vision over time.
Cyclic guanosine monophosphate-specific phosphodiesterase type 5 is an enzyme (EC 3.1.4.17) from the phosphodiesterase class. It is found in various tissues, most prominently the corpus cavernosum of the clitoris and of the penis as well as the retina. [5]
Visual phototransduction is the sensory transduction process of the visual system by which light is detected by photoreceptor cells (rods and cones) in the vertebrate retina.A photon is absorbed by a retinal chromophore (each bound to an opsin), which initiates a signal cascade through several intermediate cells, then through the retinal ganglion cells (RGCs) comprising the optic nerve.
The pigments in photoreceptor proteins either change their conformation or undergo photoreduction when they absorb a photon. [3] This change in the conformation or redox state of the chromophore then affects the protein conformation or activity and triggers a signal transduction cascade. [3] Examples of photoreceptor pigments include: [4]
It is a type of heterotrimeric G-protein with different α subunits in rod and cone photoreceptors. [1] Light leads to conformational changes in rhodopsin, which in turn leads to the activation of transducin. Transducin activates phosphodiesterase, which results in the breakdown of cyclic guanosine monophosphate (cGMP). The intensity of the ...