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The lytic cycle (/ ˈ l ɪ t ɪ k / LIT-ik) is one of the two cycles of viral reproduction (referring to bacterial viruses or bacteriophages), the other being the lysogenic cycle. The lytic cycle results in the destruction of the infected cell and its membrane.
Gammaherpesviruses are of primary interest due to the two human viruses, EBV (Epstein–Barr virus) and KSHV (Kaposi's sarcoma-associated herpesvirus) and the diseases they cause. The gammaherpesviruses replicate and persist in lymphoid cells but some are capable of undergoing lytic replication in epithelial or fibroblast cells ...
The herpes virus can then exit this dormant stage and re-enter the lytic cycle, causing disease symptoms. Thus, while herpes viruses can enter both the lytic and lysogenic cycles, latency allows the virus to survive and evade detection by the immune system due to low viral gene expression. The model organism for studying lysogeny is the lambda ...
Reactivation of latent viruses has been implicated in a number of diseases (e.g. shingles, pityriasis rosea). Following activation, transcription of viral genes transitions from LAT to multiple lytic genes; these lead to enhanced replication and virus production. Often, lytic activation leads to cell death.
Viruses may undergo two types of life cycles: the lytic cycle and the lysogenic cycle. In the lytic cycle, the virus introduces its genome into a host cell and initiates replication by hijacking the host's cellular machinery to make new copies of the virus. [12] In the lysogenic life cycle, the viral genome is incorporated into the host genome.
The human virome is the total collection of viruses in and on the human body. [1] [2] [3] Viruses in the human body may infect both human cells and other microbes such as bacteria (as with bacteriophages). [4] Some viruses cause disease, while others may be asymptomatic.
Influenza B virus is almost exclusively a human pathogen, and is less common than influenza A. The only other animal known to be susceptible to influenza B infection is the seal . [ 47 ] This type of influenza mutates at a rate 2–3 times lower than type A [ 48 ] and consequently is less genetically diverse, with only one influenza B serotype ...
Viruses are assigned according to their similarity to known lab based strains—the ΦX174-like clade, G4-like clade and the α3-like clade. The ΦX174-like clade of microviridae have the smallest and least variable genomes (5,386–5,387 bp); the G4-like clade varies in size from 5,486 to 5,487 bp; while the largest genome sized group is the ...