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Interleukin 10 (IL-10), also known as human cytokine synthesis inhibitory factor (CSIF), is an anti-inflammatory cytokine. In humans, interleukin 10 is encoded by the IL10 gene. [ 5 ] IL-10 signals through a receptor complex consisting of two IL-10 receptor-1 and two IL-10 receptor-2 proteins. [ 6 ]
Interleukin-10 receptor (IL-10R) is a type II cytokine receptor. The receptor is tetrameric , composed of 2 α [ 1 ] and 2 β [ 2 ] subunits. The α subunit (encoded in the Il10ra gene) is expressed on haematopoietic cells (such as T, B, NK, mast, and dendritic cells ) whilst the β subunit (encoded in the Il10rb gene ) is expressed ubiquitously.
The IL-10 family is a family of interleukins. In addition to IL-10, it includes IL-19, IL-20, IL-22, IL-24 and IL-26. [1] Some sources also include the interferons IL-28 and IL-29. [2] The IL-10 family are helical cytokines categorized based on their specific similarities and can be classified as class 2 cytokines. [3]
Interleukin 10 (IL-10) is a protein that inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF, and GM-CSF produced by activated macrophages and by helper T cells. In structure, IL-10 is a protein of about 160 amino acids that contains four conserved cysteines involved in disulphide bonds. [33]
It has been shown that inflammatory cytokines cause an IL-10-dependent inhibition of [24] T-cell expansion and function by up-regulating PD-1 levels on monocytes, which leads to IL-10 production by monocytes after binding of PD-1 by PD-L. [24] Adverse reactions to cytokines are characterized by local inflammation and/or ulceration at the ...
They include interleukin-1 (IL-1), IL-6, IL-12, and IL-18, tumor necrosis factor alpha (TNF-α), interferon gamma (IFNγ), and granulocyte-macrophage colony stimulating factor (GM-CSF) and play an important role in mediating the innate immune response. Inflammatory cytokines are predominantly produced by and involved in the upregulation of ...
3587 16154 Ensembl ENSG00000110324 ENSMUSG00000032089 UniProt Q13651 Q61727 RefSeq (mRNA) NM_001558 NM_008348 NM_001324486 RefSeq (protein) NP_001549 NP_001311415 NP_032374 Location (UCSC) Chr 11: 117.99 – 118 Mb Chr 9: 45.17 – 45.18 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Interleukin-10 receptor subunit alpha is a subunit for the interleukin-10 receptor. IL10RA is its ...
Interleukin 10 receptor, beta subunit is a subunit for the interleukin-10 receptor. IL10RB is its human gene. [5] IL10RB has also been designated CDw210b (cluster of differentiation w210b). The protein encoded by this gene belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex.