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The sale of mouse animal models began in 1933 with early sales to the United States Public Health Service and The Jackson Laboratory now provides a high proportion of the mice used in biomedical research [16] In particular, the C57BL/6J strain, which is widely used and cited is maintained at The Jackson Laboratory.
The NSG mouse (NOD scid gamma mouse) is a brand of immunodeficient laboratory mice, developed and marketed by Jackson Laboratory, which carries the strain NOD.Cg-Prkdc scid Il2rg tm1Wjl /SzJ. NSG branded mice are among the most immunodeficient described to date. [1] NSG branded mice lack mature T cells, B cells, and natural killer (NK) cells. [2]
The Jackson Laboratory in Bar Harbor, Maine is currently one of the world's largest suppliers of laboratory mice, at around 3 million mice a year. [5] The laboratory is also the world's source for more than 8,000 strains of genetically defined mice and is home of the Mouse Genome Informatics database. [6]
The first ob/ob mouse arose by chance in a colony at the Jackson Laboratory in 1949. [1] The mutation is recessive. Mutant mice are phenotypically indistinguishable from their unaffected littermates at birth, but gain weight rapidly throughout their lives, reaching a weight three times that of unaffected mice.
As research into continued, so did the production of mice in places like Jackson Laboratory. Facilities like these were able to produce mice for research facilities around the world. These mice were bred with Mendelian breeding technique of which Little had implemented as standard practice around 1911.
It is the most widely used "genetic background" for genetically modified mice for use as models of human disease. They are the most widely used and best-selling mouse strain due to the availability of congenic strains, easy breeding, and robustness. [1] The median lifespan of C57BL/6 mice is 27–29 months and the maximum lifespan is about 36 ...
The Jackson Laboratory was (and still is) the world's mecca for mouse genetics. From 1933 to 1934, Snell was a teacher at Washington University in St. Louis . After brief stints as teachers, in 1935 Snell joined the staff of The Jackson Laboratory in Bar Harbor on Mount Desert Island on the coast of Maine and he remained there for the entire ...
It is "the authoritative source of official names for mouse genes, alleles, and strains", which follow the guidelines established by the International Committee on Standardized Genetic Nomenclature for Mice. [6] The history and focus of Jackson Laboratory research and production facilities generates tremendous knowledge and depth which ...