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The first isolation of guanine was reported in 1844 by the German chemist Julius Bodo Unger (1819–1885), who obtained it as a mineral formed from the excreta of sea birds, which is known as guano and which was used as a source of fertilizer; guanine was named in 1846. [3]
In molecular biology and genetics, GC-content (or guanine-cytosine content) is the percentage of nitrogenous bases in a DNA or RNA molecule that are either guanine (G) or cytosine (C). [1] This measure indicates the proportion of G and C bases out of an implied four total bases, also including adenine and thymine in DNA and adenine and uracil ...
Nucleic acid thermodynamics is the study of how temperature affects the nucleic acid structure of double-stranded DNA (dsDNA). The melting temperature (T m) is defined as the temperature at which half of the DNA strands are in the random coil or single-stranded (ssDNA) state. T m depends on the length of the DNA molecule and its specific ...
Melting curve analysis is an assessment of the dissociation characteristics of double-stranded DNA during heating. As the temperature is raised, the double strand begins to dissociate leading to a rise in the absorbance intensity, hyperchromicity. The temperature at which 50% of DNA is denatured is known as the melting temperature. Measurement ...
Benzo-homologated Guanine ... (a mixed decamer of xA and T has a melting temperature of 55.6 °C, ... The energy resultant from pyrimidines ranges from 30 to 49 kJ/mol.
It has a molecular weight of 242.229 Da and a melting point of 185 °C. The stability of deoxythymidine under standard temperature and pressure (STP) is very high. Deoxythymidine is non-toxic and is part of one of the four nucleosides in DNA. It is a naturally occurring compound that exists in all living organisms and DNA viruses.
Melting temperature may refer to: Melting point, the temperature at which a substance changes from solid to liquid state; Melting temperature, the temperature at ...
Critically, the temperature at which melting occurs depends on the sequence (GC basepairs are more stable than AT due to stacking interactions, not due to the difference in hydrogen bonds [citation needed] (there are three hydrogen bonds between a cytosine and guanine base pair, but only two between adenine and thymine), so TGGE provides a ...