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The side-chain theory (German, Seitenkettentheorie) is a theory proposed by Paul Ehrlich (1854–1915) to explain the immune response in living cells.Ehrlich theorized from very early in his career that chemical structure could be used to explain why the immune response occurred in reaction to infection.
Ehrlich created the concept of magic bullet based on the development of arsphenamine and introduced the English phrase "magic bullet" in The Harben Lectures for 1907 of the Royal Institute of Public Health at London. [1] However, he had used the German word Zauberkugel in his earlier works on the side-chain theory. [3]
Paul Ehrlich around 1900 in his Frankfurt office. Ehrlich postulated that cell protoplasm contains structures which have chemical side chains (macromolecules) to which the toxin binds, affecting function. If the organism survives the effects of the toxin, the blocked side-chains are replaced by new ones.
Then the cell stops producing all other side chains and starts intensive synthesis and secretion of the antigen-binding side chain as a soluble antibody. Though distinct from clonal selection, Ehrlich's idea was a selection theory far more accurate than the instructive theories that dominated immunology in the next decades.
Paul Ehrlich (1854–1915) Described the side-chain theory of antibody formation and the mechanisms of how antibodies neutralize toxins and induce bacterial lysis with the help of complement. [45] Lichenology: Erik Acharius (1757–1819) "Erik Acharius, the father of lichenology..." [52] Microbiology
This is a topic category for the topic Paul Ehrlich ... Side-chain theory This page was last edited on 31 July 2022, at 19:28 (UTC). Text ...
Paul Ehrlich coined the term antibody (German: Antikörper) in his side-chain theory at the end of the 19th century. [8] In 1899, Ladislas Deutsch (László Detre) named the hypothetical substances halfway between bacterial constituents and antibodies "antigenic or immunogenic substances" (French: substances immunogènes ou antigènes).
[88] [89] His idea prompted Paul Ehrlich to propose the side-chain theory for antibody and antigen interaction in 1897, when he hypothesized that receptors (described as "side-chains") on the surface of cells could bind specifically to toxins – in a "lock-and-key" interaction – and that this binding reaction is the trigger for the ...