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The nuclear pore complex (NPC) is a crucial cellular structure with a diameter of approximately 120 nanometers in vertebrates. Its channel varies from 5.2 nanometers in humans [14] to 10.7 nm in the frog Xenopus laevis, with a depth of roughly 45 nm. [15]
In eukaryotes the nucleus in many cells typically occupies 10% of the cell volume. [10]: 178 The nucleus is the largest organelle in animal cells. [11]: 12 In human cells, the diameter of the nucleus is approximately six micrometres (μm). [10]: 179
3–4 μm – size of a typical yeast cell [85] 5 μm – length of a typical human spermatozoon's head [86] 6 μm – thickness of the tape in a 120-minute (C120) compact cassette [87] 7 μm – diameter of the nucleus of a typical eukaryotic cell [citation needed] about 7 μm – diameter of human red blood cells [88]
The solenoid structure's most obvious function is to help package the DNA so that it is small enough to fit into the nucleus. This is a big task as the nucleus of a mammalian cell has a diameter of approximately 6 μm, whilst the DNA in one human cell would stretch to just over 2 metres long if it were unwound. [6]
Nuclei of mouse cells (blue) containing Cajal bodies (green) visualized by fusion of p80/Coilin protein to GFP. Cajal bodies (CBs), also coiled bodies, are spherical nuclear bodies of 0.3–1.0 μm in diameter found in the nucleus of proliferative cells like embryonic cells and tumor cells, or metabolically active cells like neurons.
The megakaryoblast has a high nucleus to cytoplasm ratio with a nucleus that may be 3 to 5 times the size of the cytoplasm. The nucleus is generally oval, kidney shaped or lobed. Several nucleoli are visible, along with loose chromatin. [10] The chromatin may vary from cell to cell, ranging from fine to heavy and dense.
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The nuclear lamina is a dense (~30 to 100 nm thick) fibrillar network inside the nucleus of eukaryote cells. It is composed of intermediate filaments and membrane associated proteins . Besides providing mechanical support, the nuclear lamina regulates important cellular events such as DNA replication and cell division .