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Long-term supplementation with relatively large amounts of folic acid is associated with a small reduction in the risk of stroke [12] and an increased risk of prostate cancer. [13] There are concerns that large amounts of supplemental folic acid can hide vitamin B 12 deficiency .
Folic acid is a synthetic derivative of folate and is acquired by dietary supplementation. [25] Multi-vitamin dietary supplements contain folic acid as well as other B vitamins. Non-prescription folic acid is available as a dietary supplement in some countries, and some countries require the fortification of wheat flour, corn meal or rice with ...
There is also an elevated risk of neural tube defects among children of individuals with the C677T polymorphism (odds ratio 1.38). [6] Common MTHFR deficiencies were once thought to be associated with cardiovascular risk, but meta-analyses indicate that correlation this was an artifact of publication bias. [clarification needed] [7] [8]
The reason for this last recommendation is that nine in 10 women have such a low blood level of folic acid that they risk having a baby with a neural tube defect (NTD) – a serious birth defect ...
While there have been concerns about folic acid supplementation being linked to an increased risk for cancer, a systematic review in 2012 shows there is no evidence except in the case of prostate cancer which indicates a modest reduction in risk. [32]
A dihydrofolate reductase inhibitor (DHFR inhibitor) is a molecule that inhibits the function of dihydrofolate reductase, and is a type of antifolate.. Since folate is needed by rapidly dividing cells to make thymine, this effect may be used to therapeutic advantage.
Both high-folate diets and supplemental folic acid may help reduce the toxic side-effects of low-dose methotrexate without decreasing its effectiveness. [ 8 ] [ 9 ] Anyone taking low-dose methotrexate for the health problems listed above should consult with a physician about the need for a folic acid supplement.
Taking prescription folic acid is associated with a significantly lower risk of suicide attempts, according to a recent study published in JAMA Psychiatry. Experts say this could potentially offer ...