Search results
Results From The WOW.Com Content Network
The SOS response is a global response to DNA damage in which the cell cycle is arrested and DNA repair and mutagenesis are induced. The system involves the RecA protein ( Rad51 in eukaryotes). The RecA protein, stimulated by single-stranded DNA, is involved in the inactivation of the repressor ( LexA ) of SOS response genes thereby inducing the ...
The dimerization domain binds to other LexA polypeptides to form dumbbell shaped dimers. The DNA-binding domain is a variant form of the helix-turn-helix DNA binding motif, [4] and is usually located at the N-terminus of the protein. [1] This domain is bound to an SOS box upstream of SOS response genes until DNA damage stimulates ...
DNA repair is a collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome. [1] In human cells, both normal metabolic activities and environmental factors such as radiation can cause DNA damage, resulting in tens of thousands of individual molecular lesions per cell per day. [2]
In this case, the term PRR would encompasses all processes that facilitate the replication of damaged DNA, including those that repair replication-induced double-strand breaks. Melanoma cells are commonly defective in postreplication repair of DNA damages that are in the form of cyclobutane pyrimidine dimers , a type of damage caused by ...
RecA is a 38 kilodalton protein essential for the repair and maintenance of DNA in bacteria. [2] Structural and functional homologs to RecA have been found in all kingdoms of life. [ 3 ] [ 4 ] RecA serves as an archetype for this class of homologous DNA repair proteins.
The wildly popular 23andMe DNA test kit is marked down to just $149 (down from $199) on Amazon right now. The best part, however, is that it can arrive on time with expedited shipping.
Homology-directed repair (HDR) is a mechanism in cells to repair double-strand DNA lesions. [1] The most common form of HDR is homologous recombination . The HDR mechanism can only be used by the cell when there is a homologous piece of DNA present in the nucleus , mostly in G2 and S phase of the cell cycle .
Get AOL Mail for FREE! Manage your email like never before with travel, photo & document views. Personalize your inbox with themes & tabs. You've Got Mail!