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In contrast to regular venules, high endothelial venules are a special type of venule where the endothelium is made up of simple cuboidal cells. Lymphocytes exit the blood stream and enter the lymph nodes via these specialized venules when an infection is detected. Compared with arterioles, the venules are larger with much weaker muscular coat.
The venous system apart from the post-capillary venules is a high volume, low pressure system. Vascular smooth muscle cells control the size of the vein lumens, and thereby help to regulate blood pressure. [31] The post-capillary venules are exchange vessels whose ultra-thin walls allow the ready diffusion of molecules from the capillaries. [10]
High endothelial venules (HEV) are specialized post-capillary venules characterized by plump endothelial cells as opposed to the usual flatter endothelial cells found in regular venules. [1] HEVs enable lymphocytes circulating in the blood to directly enter a lymph node (by crossing through the HEV).
Most vessels of the microcirculation are lined by flattened cells of the endothelium and many of them are surrounded by contractile cells called pericytes.The endothelium provides a smooth surface for the flow of blood and regulates the movement of water and dissolved materials in the interstitial plasma between the blood and the tissues.
In general, arteries and arterioles transport oxygenated blood from the lungs to the body and its organs, and veins and venules transport deoxygenated blood from the body to the lungs. Blood vessels also circulate blood throughout the circulatory system. Oxygen (bound to hemoglobin in red blood cells) is the most critical nutrient carried by ...
The capillaries connect to venules, and the blood then travels back through the network of veins to the venae cavae into the right heart. The micro-circulation — the arterioles, capillaries, and venules —constitutes most of the area of the vascular system and is the site of the transfer of O 2, glucose, and enzyme substrates into the
It is very thin in veins and venules. [1] In elastic arteries such as the aorta, which have very regular elastic laminae between layers of smooth muscle cells in their tunica media, the internal elastic lamina is approximately the same thickness as the other elastic laminae that are normally present. [2]
A common pathological disorder concerning the tunica externa is scurvy, also known as vitamin C deficiency. Scurvy occurs because vitamin C is essential for the synthesis of collagen, and without it, the faulty collagen cannot maintain the vein walls and rupture, leading to a multitude of problems.