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A consensus logo is a simplified variation of a sequence logo that can be embedded in text format. Like a sequence logo, a consensus logo is created from a collection of aligned protein or DNA/RNA sequences and conveys information about the conservation of each position of a sequence motif or sequence alignment [1] [4].
PWMs are often represented graphically as sequence logos.. A position weight matrix (PWM), also known as a position-specific weight matrix (PSWM) or position-specific scoring matrix (PSSM), is a commonly used representation of motifs (patterns) in biological sequences.
In biology, a sequence motif is a nucleotide or amino-acid sequence pattern that is widespread and usually assumed to be related to biological function of the macromolecule. For example, an N -glycosylation site motif can be defined as Asn, followed by anything but Pro, followed by either Ser or Thr, followed by anything but Pro residue .
This is a graphical representation of the consensus sequence, in which the size of a symbol is related to the frequency that a given nucleotide (or amino acid) occurs at a certain position. In sequence logos the more conserved the residue, the larger the symbol for that residue is drawn; the less frequent, the smaller the symbol.
The most significant digit is an exception to this: for an n-bit Gray code, the most significant digit follows the pattern 2 n-1 on, 2 n-1 off, which is the same (cyclic) sequence of values as for the second-most significant digit, but shifted forwards 2 n-2 places. The four-bit version of this is shown below:
Similarly, the most significant bit (MSb) represents the highest-order place of the binary integer. The LSb is sometimes referred to as the low-order bit or right-most bit, due to the convention in positional notation of writing less significant digits further to the right. The MSb is similarly referred to as the high-order bit or left-most bit.
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It was a continuation of a series of character coding standards, the first one being ECMA-6 from 1965, a 7-bit standard from which ISO 646 originates. The name "ANSI escape sequence" dates from 1979 when ANSI adopted ANSI X3.64. The ANSI X3L2 committee collaborated with the ECMA committee TC 1 to produce nearly identical standards.