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Linaclotide, like the endogenous guanylin and uroguanylin it mimics, is an agonist that activates the cell surface receptor of guanylate cyclase 2C (GC-C). [12] [4] [14] The medication binds to the surface of the intestinal epithelial cells. [4] Linaclotide is minimally absorbed and it is undetectable in the systemic circulation at therapeutic ...
Ironwood (IRWD) reports positive top-line data from a late-stage study evaluating Linzess (linaclotide) for functional constipation in pediatric patients aged six to 17 years.
Plecanatide, sold under the brand name Trulance, is a medication for the treatment of chronic idiopathic constipation (CIC) [4] and irritable bowel syndrome with constipation. [5] It is available in India under the brand name Plectide (OQM Div, MSN Laboratories, India). Plecanatide is an agonist of guanylate cyclase-C.
Clothing technology describes advances in production methods, material developments, and the incorporation of smart technologies into textiles and clothes. The clothing industry has expanded throughout time, reflecting advances not just in apparel manufacturing and distribution, but also in textile functionality and environmental effect.
Pros and cons, derived from the Latin words "pro" (for) and "contra" (against), may refer to: Pros and Cons, a television series that aired from 1991 to 1992; Pros & Cons, a 1999 film starring Larry Miller and Tommy Davidson; Pros & Cons (comic strip), a comic strip by Kieran Meehan; Decisional balance sheet, a table of pros and cons
A drawstring (draw string, draw-string) is a string, rope or lace used to "draw" (gather, or shorten) fabric or other material. Ends of a drawstring are often terminated with a sheath called an aglet. The ends may be tied to hold the drawstring in place (and simultaneously close an opening).
Culottes are an item of clothing worn on the lower half of the body. The term can refer to either split skirts , historical men's breeches , or women's underpants ; this is an example of fashion-industry words taken from designs across history, languages and cultures, then being used to describe different garments, often creating confusion ...
Scotswomen walking (fulling) woollen cloth, singing a waulking song, 1772 (engraving made by Thomas Pennant on one of his tours). Fulling, also known as tucking or walking (Scots: waukin, hence often spelt waulking in Scottish English), is a step in woollen clothmaking which involves the cleansing of woven cloth (particularly wool) to eliminate oils, dirt, and other impurities, and to make it ...