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The project makes all sequence data publicly available through GenBank, an international, NIH-funded, searchable online database.This research helps to provide international researchers with the information needed to develop new vaccines, therapies and diagnostics, as well as improve understanding of the overall molecular evolution of Influenza and other genetic factors that determine their ...
They have a total genome length that is 10,000–14,600 nucleotides (nt). [7] The influenza A genome, for instance, has eight pieces of segmented negative-sense RNA (13.5 kilobases total). [8] The best-characterised of the influenzavirus proteins are hemagglutinin and neuraminidase, two large glycoproteins found on the outside of the viral ...
The influenza B virus genome is 14,548 ... response across the population. The main cause of influenza ... development has resulted in ...
Influenza viruses A and B are estimated to have diverged from a single ancestor around 4,000 years ago, while the ancestor of influenza viruses A and B and the ancestor of influenza virus C are estimated to have diverged from a common ancestor around 8,000 years ago. [40] Outbreaks of influenza-like disease can be found throughout recorded history.
The Influenza Research Database (IRD) [1] [2] [3] is an integrative and comprehensive publicly available database and analysis resource to search, analyze, visualize, save and share data for influenza virus research.
Further analysis of HA has shown it to have a very small effective population size relative to the census size of the virus population, as expected for a gene undergoing strong positive selection. [44] However, across the influenza genome, there is surprisingly little variation in effective population size; all genes are nearly equally low. [45]
Influenza A virus subtype H5N1 (A/H5N1) is a subtype of the influenza A virus, which causes influenza (flu), predominantly in birds. It is enzootic (maintained in the population) in many bird populations, and also panzootic (affecting animals of many species over a wide area). [1]
Influenza may have been brought to the Americas as early as 1493, when an epidemic disease resembling influenza killed most of the population of the Antilles. [73] [74] The first convincing record of an influenza pandemic was in 1510. It began in East Asia before spreading to North Africa and then Europe. [75]