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“I have seen a number of patients sleep better from melatonin, but I have also seen people get sleepy, unenthused or even mildly depressed with low energy well into the next day after taking ...
Melatonin has become the go-to supplement for helping Americans get a good night’s sleep. According to a 2020 survey from the Council for Responsible Nutrition (CRN), 66 percent of people who ...
Melatonin may be useful in the treatment of delayed sleep phase syndrome. [9] Melatonin is known to reduce jet lag, especially in eastward travel. However, if it is not taken at the correct time, it can instead delay adaptation. [30] Melatonin appears to have limited use against the sleep problems of people who work shift work. [31]
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Melatonin, an indoleamine, is a natural compound produced by various organisms, including bacteria and eukaryotes. [1] Its discovery in 1958 by Aaron B. Lerner and colleagues stemmed from the isolation of a substance from the pineal gland of cows that could induce skin lightening in common frogs.
These disorders include winter depression, jet lag, maladaptation to shift work and certain types of sleep disturbances. Relying on a very precise assay for plasma melatonin (a hormone that has a clearly defined 24-hour pattern of secretion), biological rhythm disorders can be assessed and their treatment can be monitored. Current research is ...